AlphaFold v2.0 and RoseTTAFold protein folding prediction workshop

A NORA workshop in collaboration with Centre for Digital Life Norway, Elixir Norway, University of Oslo and dScience. The goal of this workshop is not only to boost Norwegian and international research within protein folding and function by advanced AI methods, but also to inspire development of AI-powered biotech in Norway.

Registration here

About the workshop

In this workshop, distinguished researchers behind the AlphaFold v2.0 and RoseTTAFold algorithms will present their tools and methods. The workshop is hosted for participants who would like to get hands-on experience with the tools and methods. Both algorithms will be pre-installed on Norwegian supercomputers, and workshop participants will be tutored on how to run AlphaFold v2.0 and RoseTTAFold. See more...

Program

Day 1 

09:00-12:00 Session 1: AlphaFold and RoseTTAFold – a paradigm shift for molecular biology and biotechnology? (chaired by Klas Pettersen) 

  • 09:00-09:15 Klas Pettersen, NORA: Welcome & overview of the workshop.  

  • 09:15-10:00 Inge Jonassen, UiB: Proteins and computational techniques for predicting protein structure: an introduction to life’s molecular machines  

  • 10:00-10:10 Break  

  • 10:10-11:00: Speaker TBA: AlphaFold v2  

  • 11:00-11:10 Break 

  • 11:10 – 12:00 Sameer Valenkar, EMBL-EBI: AlphaFold Protein Structure Database 

  • 12:00-13:00 Lunch 

13:00-16:00 Session 2: Technical tutorial and hands on coding 

  • 13:00-13:30 Randy John Read, Cambridge University: Quality of Protein Structures from experiments and simulations 

  • 13:30-13:45 Break 

  • 13:45-16:00 Jonas Verhellen (technical lead): Technical tutorial on how to use our implementations of  AlphaFold v2.0 and RoseTTAFold 

  1. How to use the algorithms? 

  2. Showcase of protein examples  

  3. Try your own candidates: Work hands on with coding. Work could be in groups or individually with tutoring. 

Day 2 

09:00-13:00 Session 3: AlphaFold and RoseTTAFold – applications and limitations 

  • 09:00-10:00 Dr. Minkyung Baek, University of  Washington:  RoseTTAFold 

  • 10:00-10:30 Speaker from AstraZeneca: Implications for research, development and pharmaceutical industry  

  • 10:30-11:00 Gard Thomassen/Morten Dæhlen: The Fox server at University of Oslo and requirements for running AlphaFold v2 and RoseTTAFold  

  • 11:00-11:30 Inger Berg Ørstavik, Department of Private Law, UiO: Licensing and legal restrictions for use of AlphaFold, RoseTTAFold and AlphaFold Protein Structure Database 

  • 11:30-11:40 Break  

  • 11:40-13:00: Results/Discussion led by Jon Lærdahl (OUS & UiO) 

  • 11:40-12:00 TBA, Preliminary results 1: Unknown protein 1 and possible implications of its structure 

  • 12:00-12:20 TBA, Preliminary results 2: Unknown protein 2 and possible implications of its structure 

  • 12:40-13:00 TBA, Preliminary results 3: Unknown protein 3 and possible implications of its structure 

  • 13:00-14:00 Lunch 

14:00-15:30 Session 4: Future perspectives  

  • 14:00-14:30 Victor Greiff, UiO: Future perspectives - from structure to function 

  • 14:30-15:20: Panel Debate. (Panelists TBA)  

  • 15:20-15:30: Klas Pettersen, NORA. Closing 

Contact

NORA: contact@nora.ai

Published Aug. 11, 2021 1:37 PM - Last modified Aug. 11, 2021 1:37 PM