Intraperitoneal glucagon delivery in rats
Glucagon could play important role in glucose level normalization in diabetic patients. There is limited available information about glucagon dynamics from different parts of the body.
In a study recently published in BMJ Open Diabetes Research & Care, Ilze Dirnena-Fusini and colleagues in Artificial Pancreas Trondheim have performed a randomized controlled study to show glucagon absorption dynamics from intraperitoneal, subcutaneous and intravenous routes. The paper is available here.
It was found that glucagon injected intraperitoneally gives a higher glucose response 4 min after administration and affects blood glucose for a shorter period compared with subcutaneous injection. The present results should encourage research on the feasibility of combined intraperitoneal administration of insulin and glucagon as part of an artificial pancreas in humans.