From single enzymes to enzyme systems – OxyMod leads the way

While enzyme discovery for biomass processing is a well-known activity practiced world-wide, and while many individual enzymes are well studied, OxyMod is unique in that it studies enzyme systems.

The efficiency of LPMOs in breaking down cellulose is affected by multiple other redox enzymes as well as redox mediators. Thus OxyMod attempt to do systems analysis rather than studying individual enzymes. Picture taken from Kracher et al., Extracellular electron transfer systems fuel cellulose oxidative degradation, 2016, Science 352:1098-1101. doi: 10.1126/science.aaf3165. Epub 2016 Apr 28.

In particular, OxyMod focuses on the most novel, innovative and challenging of these systems, namely redox enzyme systems that revolve around the unique Lytic Polysaccharide Monooxygenases (LPMOs) that were discovered at NMBU in 2010 (with a prelude in 2005). The discovery of LPMOs and, more so the discovery that these enzymes need reducing equivalents and hydrogen peroxide to function optimally, has shed a completely new light on the (possible) roles on many other redox enzymes and redox-active components that occur in biomass-degrading eco-systems and that may be as important for industrial biomass processing as, for example, classical cellulases.

OxyMod research at NMBU shed light on these issues in a recent review paper: Sugar oxidoreductases and LPMOs - two sides of the same polysaccharide degradation story? Manavalan T, Stepnov AA, Hegnar OA, Eijsink VGH. Carbohydrate Research 2021 Jul;505:108350. doi: 10.1016/j.carres.2021.108350.

 

Published Feb. 3, 2022 10:22 AM - Last modified Mar. 23, 2023 9:30 AM