'Tissue is the issue': a multi-omics approach to improve prostate cancer diagnosis
The main goal of the ProstOmics project is to improve diagnosis and prognosis of prostate cancer. The project will investigate relevant biomarkers and molecular pathways to discriminate aggressive from indolentslow-growing cancer. New biomarkers can avoid overtreatment and reduce work-load and economicburden for the health-care system and at the same time improve patient quality of life.
TheProstOmics project is highly transdisciplinary in using various in-front methodology within -omicsdata especially focusing on spatial information and the study of microenvironment andheterogeneity. The project have therefore several national and international collaborators within several ofthese scientific fields.
The project use integration of -omics technology (metabolomics, transcriptomics, genomics, proteomics, metallomics) to study tissue samples and biofluids (urine, blood) from large-scale biobanks of prostate cancer patients. The main research aim is to discover and validate biomarkers and molecular signatures for separating aggressive from indolent prostate cancer.