Listening to the patients
Listening to their gut to improve the lives of people with type I diabetes.
During 2021, our research has focused on map the different abdominal sounds to be used for early meal detection in an artificial pancreas. During this work we have also identified a couple of unexpected sensing modalities that can supplement abdominal sounds for early meal detection.
One highlight of 2021 has been that we by this combined approach are able to identify most meals within minutes after meal initiation. For us the added value of being a part of a transdisiplinary centre is the inspiration we get from the great diversity of projects and the interaction for both the students and the senior participants in the project.
Project lead: Sven Magnus Carlsen
Partner: SINTEF Digital AS
Funding: Research Council of Norway
Duration: 4 years (2019–2022)
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See also Artificial Pancreas Trondheim (APT) and the Double Intraperitoneal Artificial Pancreas (DIAP) project, SINTEF Digital and Prediktor Medical
Former MSc student
Anders Lyngvi Fougner
- Dag Roar Hjelme
Former MSc student
Ingrid Anna Teigen
Nora Lyngstad Røste
Former MSc student
Pallavi Ajay Patil
- Project lead: Sven Magnus Carlsen
Sunilkumar Telagam Setti
Former postdoctoral research fellow
- Øyvind Stavdahl
Listening to the Patients is developing sound-based meal detection system to improve artificial pancreases. Timing insulin delivery with a meal is an important part of controlling blood glucose levels and avoiding long-term complications. Accomplishing this high-risk goal will be a major step toward improving the lives of people with diabetes.
Many people with type I diabetes are treated with glucose monitors and insulin pumps delivering insulin in subcutaneous tissue. By combining a glucose monitor and an insulin pump one can make a devise delivering insulin based on the measured glucose levels. Such a devise is called an artificial pancreas. However, subcutaneous insulin delivery carries inherent delays in the effect on glucose levels making it hard to achieve good glucose control.
To reduce the delays associated with the subcutaneous approach, the Artificial Pancreas Trondheim (APT) research group work on intraperitoneal glucose monitoring and delivery, i.e. between the intestines. With this “double intraperitoneal” approach for an artificial pancreas the absorption of insulin and the effect on glucose levels are much faster.However, such an artificial pancreas will still struggle to handle increasing glucose levels after meals. It takes at least 30 minutes for the artificial pancreas to detect this rise after a meal, far too long a delay to control glucose properly. Over time, insufficient glucose control can lead to long-term issues like kidney disease, cardiovascular disease or even blindness.
Listening to the Patients’s bold new approach analyzes sounds in the gastrointestinal tract with external microphones for telltale sounds of a meal. The researchers will correlate this information with blood glucose levels to administer the correct dosage of insulin much closer to meal intake than current devices. In a recent pilot study, they were able to detect a meal in as little as 10 minutes after consumption.
This research has great potential for developing a vastly improved artificial pancreas, but it is also highly risky: their detection algorithm must be extremely accurate because administering a meal dose of insulin to a patient that has not eaten can be deadly. To ensure their algorithm meets this high standard, the Listening to the Patients team consists of engineering physicists, sound engineers, cyberneticists, physicians, and endocrinologists. They are using machine learning based on the principles of speech recognition and their knowledge of engineering and physiology to identify meal sounds and eliminate extraneous sounds. They expect to have a proof of concept listening device ready for testing within one year.
The Listening to the Patients team is working closely with people with diabetes to ensure a positive user experience. Privacy is a major concern with audio systems so their algorithm will identify and eliminate speech from the recordings. When fully developed, the system will analyze data real time and not store sound recordings.
Listening to the Patients project is part of the Artificial Pancreas Trondheim (APT) research group at The Norwegian University of Science and Technology (NTNU) in Trondheim. It is funded by the Research Council of Norway and is one of the multidisciplinary research projects within Centre for Digital Life Norway.
Latest news from the project
- Marte Kierulf Åm interviewed by Technoport June 24, 2021 3:22 PM
- PhD Research Fellowship NTNU Dec. 7, 2020 2:00 PM
- Intraperitoneal and Subcutaneous Glucagon Delivery in Anaesthetized Pigs Nov. 8, 2020 4:14 PM
- Mid-infrared spectroscopy with a fiber-coupled tuneable quantum cascade laser for glucose sensing Feb. 28, 2020 2:37 PM
- Exploring Tools to Understand Control Mechanisms in Biology June 11, 2019 12:13 PM
- Prizes for transdisciplinary publications in DLN - the 2018 awards Mar. 27, 2019 9:44 AM
- Micro-lenses on fibers for glucose monitoring in diabetes Mar. 24, 2019 7:21 PM
- Intraperitoneal glucagon delivery in rats Nov. 11, 2018 7:50 PM
- Does it matter where in the peritoneal space an artificial pancreas is placed? Oct. 24, 2018 12:42 PM
- The performance of Flash Glucose Monitoring Oct. 24, 2018 12:28 PM