Drug discovery is a long marathon and our athletes need all the help they can get. This is a challenge we, in RESPOND3, want to answer to through the development of better computational methods. This is a highly interdisciplinary Digital Life Norway project that strives to replicate the dynamic of an early drug discovery project – a bold project for academia to venture in if we have in mind that the development of a new drug takes a long time and millions upon millions of dollars – but let us not get intimidated by that! The current pandemic has slowed down our pace, but now we are moving forward with monthly meetings (digital of course) to share and discuss our collective scientific efforts.