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BT8120 - PhD course in Prokaryote and synthetic biology

This course will provide you with an understanding of the physiology of the microbial cell and how it can be manipulated. In the first part, the focus will be on molecular biology and physiology, emphasizing topics that are important for synthetic biology. The second part focuses on the approaches and tools directly utilized in synthetic biology and are organized in the order of a typical workflow of a strain design project (Design, Build, Test, Learn).

Time and place: –, NTNU, Trondheim

Registration is closed.


NTNU students should apply through studweb, external students as described at http://www.ntnu.edu/studies/researchcourses.

 

This course consists of 2 three-day meetings at NTNU, Trondheim. 

Time: Mondays 11.00-17.00, Tuesdays and Wednesdays 9.00-16.00

First meeting: 6 February - 8 February

Second meeting: 27 February - 1 March

 

Topics:

Part 1: Basic prokaryote molecular biology and physiology

  1. Gene expression and regulation
  2. Growth and Bioenergetics
  3. Secondary metabolism
  4.  Cell differentiation, communication, and interactions
  5. Coordination and regulation of microbial metabolism
  6.  Genetic engineering and genome editing techniques including CRISPR

Part 2:  Synthetic Biology

  1. Genetic circuits
  2. Computational Strain Design
  3. CADesign, automated construction and expression of synthetic pathways
  4. Computational Strain Design
  5. Omics technologies
    1. Genomics and transcriptomics
    2. Proteomics
    3. Metabolomics, fluxomics, lipid 
  6. Guest lecture

 

Knowledge: The successful student will acquire fundamental knowledge of prokaryote molecular biology and physiology at an advanced level as well as knowledge about recent advances in prokaryote molecular biology. For the topics on genetic circuits and -omics technologies, the aim is to obtain an understanding of what these approaches may contribute to a project. 

 

Practical information: The course will be given in English. The course material will consist of the equivalent of 300 pages book chapters, Papers and lecture notes.  The grade (passed/not passed) is given based on a group assignment (20 %) and a semester test (80 %). See https://www.ntnu.edu/studies/courses/BT8120#tab=omEmnet for more information on BT8120.

NTNU students should apply through studweb, external students as described at http://www.ntnu.edu/studies/researchcourses. The deadline is January 27th. If you apply later than January 10th please contact the course coordinator to get an early access to the course materials, you are supposed to be prepared for the lectures. Ertesvåg can also give further information on the course.

 

The course is supported by the Digital Life Norway Research School and there are a limited number of travel grants available for our members. 

 

Contact course coordinator:

Helga Ertesvåg (helga.ertesvag@ntnu.no)

Published Dec. 7, 2022 1:47 PM - Last modified May 4, 2023 2:47 PM
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